South Carolina is a sun-kissed blend of towering oaks, salt-kissed air, and timeless Southern hospitality. From the cobblestoned charm of Charleston to the family-friendly shores of Myrtle Beach, the Palmetto State offers vacation rentals and holiday rentals that fit every pace. Whether you’re planning a beach escape, a nature-filled road trip, a golf getaway, or a cultural deep dive, you’ll find flexible stays that feel like a home away from home. This guide showcases the best South Carolina destinations, mobile accommodation options, must-do activities, and local experiences, with practical tips to help you plan your perfect trip. When you’re ready to book, remember that searchandstay.com is a great resource to find accommodations in the area and compare vacation rentals South Carolina offers in a single, travel-friendly search.
Why South Carolina vacation rentals and holiday rentals are perfect for every traveler
Vacation rentals in South Carolina provide space to spread out after a day of exploring, kitchens to cook up fresh catches from the harbor, and living areas designed for social moments with family or friends. Whether you’re chasing a beachfront condo with ocean views, a cozy cottage in a historic town, or a luxury villa on a private island, holiday rentals South Carolina style give you the freedom to set your own schedule. From the Lowcountry’s tidal marshes to the Upstate’s rolling hills, you can choose stays that put accessibility, comfort, and local flavor first. If you’re coming with a group, a well-appointed vacation home can offer multiple bedrooms, outdoor spaces, and private pools, making it easier to blend excitement with downtime.
For travelers who want flexibility, “Mobile Accommodation” options—such as RV parks, glamping sites, and motorhome-friendly campgrounds—offer a different rhythm. Coastal highways, scenic byways, and state parks make it simple to combine scenic drives with convenient places to sleep, often with easy access to fishing piers, boat ramps, and nature trails. When you search for accommodations, think about the pace you want: a full-on beach week, a culture-and-food circuit, or a nature-centric escape with day trips to waterfalls and lookout points. No matter your preference, there are South Carolina vacation rentals that align with your travel style.
Top South Carolina destinations for vacation rentals and holiday rentals
Here are some of the most popular corners of the state for a memorable stay, each with its own vibe, activities, and family-friendly or couple-friendly appeal.
Charleston and the Lowcountry
Charleston remains a magnet for travelers seeking history, architecture, and a thriving culinary scene. Book a vacation rental in the Historic District and wake up within steps of centuries-old houses, cobblestone streets, and waterfront views. In-town options range from elegant townhomes to modern condos overlooking the battery or the harbor. If you crave a more secluded retreat, consider a coastal villa on nearby islands or a marsh-side cottage in Mount Pleasant or Isle of Palms.
- Walkable neighborhoods with access to rooftop bars, garden courtyards, and horse-drawn carriages.
- Plantation tours, harbor cruises, and a sunset sail from the Charleston Harbor.
- Gourmet experiences featuring Lowcountry boil, she-crab soup, shrimp and grits, and farm-to-table dining.
Myrtle Beach and the Grand Strand
For something family-friendly with options for all ages, Myrtle Beach is a crowd favorite. Beachfront vacation rentals and holiday rentals along the Grand Strand put you within easy reach of the boardwalk, amusement parks, and endless sea breeze. Choose a spacious condo or a seaside house with a private deck and a splash-friendly pool. The area offers a broad mix of activities—from miniature golf and water parks to fishing charters and outlet shopping—ensuring there’s never a dull moment for kids or adults.
- Boardwalk fun, live entertainment, and kid-friendly attractions.
- Professional golf courses hugging the coastline for a true seaside swing.
- Sunrise walks on the beach, dolphins offshore, and tasty seafood shacks along the inlet.
Kiawah Island, Seabrook Island, and Hilton Head Island
These barrier islands are known for pristine beaches, pristine golf courses, and world-class resorts. Vacation rentals here often come as luxury villas, oceanfront condos, or nature-forward homes tucked into maritime forests. It’s the kind of place where you can ride bikes along serene paths, spot deer and sea birds, and end each day with a sunset view that washes the shoreline in golden light.
- Kiawah’s acclaimed golf courses and wildlife-filled marshes provide a refined yet relaxed escape.
- Islands offer private beach access, resort-style amenities, and chef-driven dining.
- Kayaking, paddleboarding, and wildlife tours are easy to arrange from your vacation rental base.
Beaufort and the South Carolina Lowcountry
Beaufort’s antebellum architecture and coastal charm create a slow, friendly vibe that’s perfect for romantic getaways and cultural explorations. A historic home in the town’s leafy lanes makes a memorable backdrop for a long weekend, while a marsh-side cottage invites birdwatching, crabbing, and marsh sunset views. The nearby islands and waterfront eateries offer fresh seafood with a side of maritime history.
- Stroll shaded streets lined with live oaks and Spanish moss.
- Historic tours, boat excursions, and local ghost stories for a touch of adventure.
- Beach days nearby on Fripp Island and Hunting Island State Park.
Upstate and Blue Ridge Escapes (Greenville, Travelers Rest, and Beyond)
For travelers who want a break from the coast, South Carolina’s Upstate delivers mountains, waterfalls, breweries, and a vibrant arts scene. A vacation rental nestled near Falls Park in Greenville or along the Swamp Rabbit Trail becomes your launching pad for outdoor adventures, morning coffee in cozy cafes, and evenings filled with live music or farm-to-table dining.
- Hiking in state parks, waterfall hikes, and scenic drives through the foothills.
- Farm-to-table restaurants and craft breweries that reflect the region’s fresh flavors.
- Local markets and street fairs that celebrate Southern hospitality and community.
Mobile accommodations and flexible stays: where to rest on the move
Mobile accommodations in South Carolina let you combine the freedom of a road trip with comfortable places to sleep. Think RV parks with full hookups near the beach, glamping tents tucked into coastal forests, or motorhome-friendly campgrounds near river accesses. These options are ideal for travelers who want to explore multiple destinations in one trip, or for groups that value easy parking and quick access to outdoor activities.
- Coastal RV parks with sea breezes, access to fishing piers, and proximity to nightlife or quiet dunes.
- Glamping sites that bring the comforts of home to nature—comfortable beds, lighting, and sometimes hot showers amid pine forests or marsh meadows.
- Family-friendly campgrounds close to amusement parks, water parks, and shopping centers for a balanced itinerary.
When planning with mobile accommodations, consider the rhythm of your days: early morning beach walks followed by a midday snack, or late-night stargazing after a day on the water. These stays can be powerful anchors for a multi-destination South Carolina itinerary, letting you switch from city culture to outdoor adventures with ease.
Activities and experiences that make South Carolina sing
South Carolina is a playground for active travelers, food lovers, culture seekers, and anyone who loves a good story told with southern charm. Here are some experiences that showcase the best of the state’s destinations and the kinds of adventures you can base your vacation rentals around.
Coastal adventures
- Beach days on wide sandy shores—from Myrtle Beach’s lively stretch to Kiawah and Seabrook’s pristine sands.
- Water activities like surfing on the Atlantic, sailing charters, kayaking through marsh creeks, and paddleboarding at dawn.
- Fisheries and seafood charters in Murrells Inlet and Charleston’s harbor for a hands-on culinary experience.
Historic and cultural explorations
- Charleston’s walking tours, carriage rides, and centuries-old architecture tours.
- Plantation visits near Charleston and Beaufort for a glimpse of history and landscape.
- Art galleries, theaters, and music venues in Greenville and Charleston that reflect a vibrant arts scene.
Outdoors and wildlife
- Hiking in Table Rock, Caesar’s Head, and Poinsett state parks; scenic drives along the Cherokee Foothills scenic byway.
- Birdwatching and marsh tours in the Lowcountry; alligators and dolphins spotted along coastal waterways.
- Golf on famous courses in Hilton Head, Kiawah, and Myrtle Beach—perfect for a sunny, social round with friends.
Food, drink, and local flavors
- Lowcountry cuisine: shrimp and grits, she-crab soup, and a Louisiana-style crawfish boil with a Southern twist.
- Barbecue trails, seafood shacks, and farmers markets offering regional produce and handmade goods.
- Wine and craft beer tastings in the Upstate and along coastal towns.
Planning tips for a seamless South Carolina vacation
To get the most from your trip, a little planning goes a long way. Here are practical tips to help you select the right accommodations and build a memorable itinerary around South Carolina’s highlights.
- Match your pace to your destination: Charleston offers history and dining at a walkable scale, while Myrtle Beach is ideal for a more action-packed family vacation with entertainment options right outside your door.
- Consider a split stay: spend several nights in a beachfront condo along the Grand Strand, then shift to a quiet country villa in the Upstate for a cool-down after a day of hiking.
- Book in advance for peak seasons: summer weekends, spring break, and holiday weeks fill up fast for vacation rentals. Use a comparison site like searchandstay.com to find the best options and rates.
- Factor in local experiences: reserve space on a guided plantation tour, a Charleston harbor cruise, or a food-focused walking tour to deepen your trip.
- Plan for mobile accommodations if you want to cover multiple spots: an RV park base can minimize packing and maximize beach time.
Where to find the best South Carolina vacation rentals and holiday rentals
To discover a wide range of accommodations—whether you’re searching for beachfront rentals, downtown apartments, family-friendly homes, or off-the-beach retreats—start with a trusted source that aggregates options across the state. Using a dedicated vacation rental search platform makes it easier to compare features, check availability, and read reviews from fellow travelers. For those planning a South Carolina trip, searchandstay.com is a convenient place to find accommodations in the area, from luxury island villas to cozy cottages, with filters that help you prioritize proximity to the beach, pet-friendly spaces, or pool access. When you book through a reputable site, you’ll also benefit from clear cancellation policies, updated photos, and verified listings that align with your vacation rental South Carolina goals.
Key search considerations when browsing vacation rentals and holiday rentals in South Carolina include:
- Proximity to the beach, marina, or city center—decide what kind of access matters most for your trip.
- Family-friendly features like kid-safe furniture, high chairs, cribs, and a fenced yard for dogs if you’re traveling with pets.
- Outdoor spaces such as balconies, decks, patios, and private pools for social evenings outdoors.
- On-site amenities like laundry facilities, well-equipped kitchens, fast Wi-Fi for remote work or streaming, and parking availability.
- Flexible arrival dates, pet policies, and reputable host or management company ratings to ensure a smooth experience.
Seasonal planning: best times to visit South Carolina
South Carolina shines across seasons, but different months align with different vacation rental experiences. Here’s a quick guide to help you choose the right time to book your vacation rental South Carolina style.
- Spring (March–May): Perfect for outdoor adventure, blooming gardens, and comfortable beach days. It’s shoulder-season pricing in many areas, so you can find good value on vacation rentals.
- Summer (June–August): Peak season along the coast. Expect lively beaches, festivals, and longer daylight hours. Book early to secure the best vacation rentals and family-friendly activities.
- Fall (September–November): Cooler temps, fewer crowds, and excellent conditions for golf and outdoor exploration. Coastal towns still buzzing, with many seasonal events and seafood tastings.
- Winter (December–February): Off-season opportunities for culture and cuisine experiences, plus lower rates on long weekend stays. Some coastal attractions may have reduced hours, but major cities maintain dining and entertainment options.
Make the most of your South Carolina stay
With a solid plan and the right vacation rental, you can craft a South Carolina itinerary that balances exploration with relaxation. Here are some practical ideas to tailor your trip to your interests:
- Family-first island breaks: base yourself in a Myrtle Beach or Hilton Head rental, spend mornings on the sand, afternoons at water parks, and evenings exploring town centers with kid-friendly eateries.
- Romantic getaways: choose a coastal villa in Kiawah or Seabrook Island, enjoy sunset beach walks, and savor fine dining in quiet, intimate settings.
- Food and culture expeditions: use Charleston as your hub, take day trips to nearby plantations, and join a culinary walking tour to sample Lowcountry flavors in multiple neighborhoods.
- Nature and active travel: start in Greenville for Falls Park and the Swamp Rabbit Trail, then venture to a mountain parish for hiking and scenic overlooks before cooling off by the water.
- Weekend warrior golf trips: book a series of stays at or near top-rated courses in Hilton Head, Kiawah, and Myrtle Beach to maximize rounds and relaxation time.
Closing thoughts: your next South Carolina adventure
South Carolina offers a singular blend of beaches, culture, cuisine, and warm hospitality, all accessible through a wide range of vacation rentals and holiday rentals. Whether you’re drawn to the historic charm of Charleston, the family-friendly energy of Myrtle Beach, the luxury and serenity of island getaways, or the mountain-air freshness of the Upstate, you’ll find a home base that amplifies your travel joys. By prioritizing flexible stays, easy booking through a trusted site like searchandstay.com, and a carefully crafted mix of activities, you’ll build a South Carolina getaway that’s unforgettable for everyone involved.
Ready to start planning? Explore available accommodations, compare options, and confirm your dates—your next South Carolina adventure is just a few clicks away. Whether you’re booking a beachfront condo, a family retreat in a plantation-adjacent neighborhood, or a mobile-friendly camp or glamping site for a road-tripping itinerary, South Carolina vacation rentals offer a pace that fits your story. Happy travels, and may your suitcase be light, your memories abundant, and your experiences inclusive and joyful.

